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By Annaby M.H., Mansour Z.S.

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Haemocytes from the anterior and posterior ends of the embryo migrate towards one another along the ventral nerve cord (3) and the developing gut (not shown) until the anterior and posterior populations meet (4). During this stage, haemocytes continue to migrate posteriorly on the dorsal side of the embryo along the developing dorsal vessel (5). b | Migration along the ventral nerve cord is directed by PVF signals. At stage 10, Pvf3 (blue) is strongly expressed along the ventral midline. At stage 12, haemocytes (green) migrate along the developing nerve cord from the posterior and anterior ends (arrows), attracted by the expression of Pvf3 (blue) and Pvf2 (red).

Protein-only’ hypothesis This hypothesis proposes that the prion is devoid of informational nucleic acid and that the essential pathogenic component is a protein or glycoprotein. Scrapie prion protein (PrPSc). An abnormal form of the mature PRNP gene product that is found in tissues of patients with TSE, defined as being partially resistant to proteinase-K digestion under standardized conditions. It is believed to differ from PrPC conformationally and is considered to be the main transmissible agent or prion.

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