By Philip M. Parker
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Additional resources for 3-Methylcrotonyl-Coenzyme A Carboxylase Deficiency - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers
Such disorders are more difficult to analyze because their genetic causes are often unclear, and they do not follow the patterns of inheritance described above. Examples of conditions caused by multiple genes or gene/environment interactions include heart disease, diabetes, schizophrenia, and certain types of cancer. Disorders caused by changes in the number or structure of chromosomes do not follow the straightforward patterns of inheritance listed above. Other genetic factors can also influence how a disorder is inherited.
A trinucleotide repeat is a sequence of three DNA building blocks (nucleotides) that is repeated a number of times in a row. DNA segments with an abnormal number of these repeats are unstable and prone to errors during cell division. The number of repeats can change as the gene is passed from parent to child. If the number of repeats increases, it is known as a trinucleotide repeat expansion. In some cases, the trinucleotide repeat may expand until the gene stops functioning normally. This expansion causes the features of some disorders to become more severe with each successive generation.
A genetics professional will NOT: • Tell a person which decision to make. • Advise a couple not to have children. 44 3-Methylcrotonyl-Coenzyme a Carboxylase Deficiency • Recommend that a woman continue or end a pregnancy. • Tell someone whether to undergo testing for a genetic disorder. How Can I Find a Genetics Professional in My Area? To find a genetics professional in your community, you may wish to ask your doctor for a referral. If you have health insurance, you can also contact your insurance company to find a medical geneticist or genetic counselor in your area who participates in your plan.